With the development of society and the improvement of people’s living standards, the prevalence of diabetes is increasing year by year, and it is estimated that there are about 92.4 million people with type 2 diabetes and 148 million people with prediabetes in China; various chronic comorbidities and complications of diabetes such as coronary heart disease, hypertension, hyperlipidemia, fatty liver, hyperuricemia (gout), obesity, and diabetic retinopathy, diabetic peripheral nerve, vascular lesions, diabetic nephropathy, diabetic autonomic neuropathy (abnormal sweating, constipation, diarrhea, urinary frequency, urinary incontinence, etc.) are also significantly higher. In 2010, China spent about 170 billion yuan on health expenditure on diabetes, of which about 85% was spent on the treatment of comorbidities and complications of diabetes. The prevention and treatment of various risk factors of diabetes and the prevention and treatment of diabetes complications and comorbidities have become the key issues in diabetes treatment. As a disease with multiple risk factors (blood glucose, blood lipids, blood pressure, body weight, platelet aggregation, etc.) and long-term chronic disease control, the prevention and treatment of diabetes is consistent with the philosophy of Chinese medicine’s holistic concept, discriminatory treatment, and treatment of the untreated disease. According to Chinese medicine, the causes of diabetes are related to congenital factors, weakness of the five organs, and acquired environmental and dietary factors, such as over-eating fat and sweet, less movement and more escape, and physical obesity. The disease is divided into yin deficiency and heat, qi and yin deficiency, yin and yang deficiency, and phlegm (dampness), blood stasis, or depression and heat, involving the lung, stomach, spleen, kidney, liver, heart and other internal organs deficiency. The treatment starts from nourishing Yin and clearing heat, benefiting Qi and nourishing Yin, nourishing Yin and tonifying Yang, removing phlegm and turbidity, activating blood circulation and removing stasis, and relieving depression and clearing heat. According to the patient’s constitution and condition, the Chinese medicine cream formula can be administered according to the patient’s body condition, to supplement the deficiency and help the weakness, to treat the disease and correct the bias, and to treat the disease in the midst of the supplement, which has a positive effect on the prevention and treatment of diabetes and its complications and comorbidities from a holistic approach, and to prevent the disease before it occurs. The selection of diabetic patients need to pay attention to matters: 1, adhere to the overall concept of Chinese medicine, individualized treatment, disease identification and evidence-based treatment, taking into account the characteristics of “cure” and “supplementation of deficiency”, the balance of qi and blood, the five organs smooth, people that is peace and harmony, do not blindly indiscriminate supplementation, do not distinguish between 2, in considering the application of various sugars such as rock sugar, white sugar, brown sugar, syrup, honey, etc. to correct the taste, easy to take the cream, but also need to consider the impact of sugar on blood sugar, appropriate in the cream medicine to add some sweeteners, such as xylitol, stevia, Yuanzhen sugar, etc.; high sugar content of roasted licorice, dates, jujube paste, longan meat also used in moderation; 3, in the selection of drugs, can be appropriate Combine with modern pharmacological research to select drugs. Such as the role of regulating blood sugar drugs such as Ge Gen, Zhi Mu, Astragalus, Atractylodes, Di Jin Cao, Mai Dong, Cornu Cervi Pantotrichum, etc.; regulating blood lipids drugs such as Hawthorn, cassia seeds, turmeric, Ze Di, Pu Huang, etc.; 4, diabetic patients who are older, have a variety of comorbidities, such as due to acute changes in the condition or combined with external sensations, infection should be suspended; In addition, diabetic patients with spleen deficiency and poor digestive function, or have obvious digestive tract If necessary, it can be combined with the medicine to help transport and strengthen the spleen.