Multiple gallbladder stones are dangerous and it is advisable to consult a gastroenterologist or hepatobiliary surgeon. Multiple gallbladder stones may cause acute and chronic cholecystitis, gallbladder cancer, etc. Patients may have abdominal pain, nausea, vomiting, jaundice, etc., but some of them may have no self-consciousness for the time being, and be detected by liver and gallbladder ultrasound and other examinations. The specific risk is related to the patient’s underlying condition, stone size, duration of illness and other factors. It is recommended that patients with multiple gallbladder stones should consult the gastroenterology department or hepatobiliary surgery department in a timely manner and follow the doctor’s advice to formulate the next management measures. Meanwhile, it is necessary to pay attention to low-fat diet, regular meals, appropriate exercise to control weight, and active treatment of co-morbidities such as hypertension, diabetes mellitus, high blood cholesterol, fatty liver.