Radix et Rhizoma Ginseng, Poria, Glycyrrhizae, Atractylodes Macrocephalae is a variation of the classic Chinese medicine formula, Si Jun Zi Tang, which uses ginseng instead of Radix et Rhizoma Ginseng, and the combination of the four herbs has the effect of benefiting qi and strengthening the spleen (regulating the qi of the spleen and stomach). Four Gentlemen Tang is composed of ginseng, atractylodes, poria, and licorice. Currently, ginseng is often used as a substitute for ginseng in clinical practice, as ginseng is milder and cheaper than ginseng, and the combination of the four herbs has the effect of benefiting qi and strengthening the spleen, and can be used in the case of deficiency of qi in the spleen and stomach, which is generally manifested as yellowish color (yellowish and lack of luster), low tone of voice, shortness of breath and fatigue, and loose stools with scanty food (scanty and unshapely feces). Codonopsis Poria, Glycyrrhiza glabra and Rhizoma Atractylodis Macrocephalae can be used for the treatment of withered and white color of the face, low voice, shortness of breath, loose stools, pale tongue, white fur, and weak and slow pulse. Adverse drug reactions and contraindications are not clear. The use of Chinese medicines should be under the guidance of a professional Chinese medicine practitioner, and should not be taken on its own.