Male urethritis, including gonococcal urethritis, non-gonococcal urethritis and urethritis caused by intestinal pathogens, gonococcal urethritis is mainly treated with cephalosporins, such as ceftriaxone; non-gonococcal urethritis is mainly treated with minocycline, and spouses need to be treated at the same time; urethritis caused by intestinal pathogens can be orally taken with cephalosporin antibiotics. 1. Gonococcal urethritis: cephalosporin-based drug therapy, commonly used ceftriaxone, cefixime, etc., serious cases can be combined with quinolones, generally 7 to 14 days a course of treatment. The patient’s spouse should be treated at the same time to avoid cross-infection. 2. Non-gonococcal urethritis: the pathogenic bacteria are mainly chlamydia, trichomonas, etc. Minocycline, erythromycin, azithromycin, metronidazole drugs are commonly used in the treatment, and the spouse also needs to be treated at the same time. 3. Urethritis caused by intestinal pathogens: For urethritis caused by intestinal pathogens, cephalosporin antibiotics can be used, such as ceftriaxone, ceftazidime and so on. The treatment of male urethritis should first be diagnosed clearly, and choose the appropriate treatment program after clear diagnosis. All of the above drugs need to be applied under the guidance of a doctor.