Atypical chronic granulocytic leukemia refers to atypical chronic granulocytic leukemia, which is generally difficult to cure (treat). Atypical chronic granulocytic leukemia is a myeloproliferative disease, mostly seen in middle-aged and old-aged people. Patients may suffer from anemia, fever, infection, bleeding and other symptoms due to blood cell abnormalities, and at the same time may be accompanied by lymph node enlargement and other symptoms; generally, active treatment can effectively control the symptoms and prolong the survival period, but this disease is generally difficult to cure. Atypical chronic granulocytic leukemia needs to be treated with tyrosine kinase inhibitors under the guidance of a doctor, and patients should have regular follow-up chemotherapy. After diagnosed with atypical chronic granulocytic leukemia, patients need to protect themselves from cold and warmth, prevent infection, avoid acute attacks and worsening of symptoms; usually pay attention to clean and light diet. This disease is highly specialized, should go to regular hospitals in a timely manner, under the guidance of the doctor to determine the specific treatment plan, and actively cooperate with the treatment to avoid deterioration of the condition.