Long-acting contraceptive pills may lead to menstrual irregularities, endocrine disorders and other hazards after taking them. 1. Irregular menstruation: the main components of long-acting contraceptives are estrogen and progesterone, which will affect the normal function of the ovaries and inhibit ovulation, leading to irregular menstruation, reduced menstrual flow, delayed menstruation and even amenorrhea after taking them. If you take long-acting contraceptives for a long time, it may also lead to abnormal ovulation, triggering female infertility. 2. Endocrine disorders: hormonal drugs, after taking them, are likely to lead to endocrine disorders, weight gain, excessive obesity, acne pigmentation and other phenomena, causing gastrointestinal reactions, nausea, vomiting, anorexia and other symptoms, but also may lead to breast distension and pain, abdominal pain, heart palpitations and other side effects. Therefore, long-acting contraceptives are more harmful and women are advised to use condoms or short-acting contraceptives and other methods of reasonable contraception.