Immunohistochemistry CD68+ indicates that the relevant tissues/cells tested express CD68, which is suggestive of histiocytic lymphoma, xanthoma, some cancers, etc. It needs to be judged on a case-by-case basis. CD68 is a glycoprotein, monoclonal antibody has two kinds, KP-1 and PG-M1, KP-1 marks monocytes, macrophages and myeloid cells, PG-M1 only marks monocytes and macrophages, not myeloid cells, the commonly used antibody is KP-1, that is, it is often used as a marker for detecting macrophages in tumor tissues. It mainly marks histiocytic (monocyte) lesions, such as juvenile yellow granuloma, xanthoma, fibroxanthoma, and histiocytic lymphoma; in addition, reactive histiocytes and osteoblastic multinucleated giant cells in some tumors, and epithelioid histiocytes in nodules or tuberculosis also express CD68. However, CD68 is not a histiocyte-specific marker. Soft tissue granulosa cell tumors, melanotic tumors, and some cancers (e.g., breast cancer, gastric cancer) may also express CD68. It is recommended to go to a regular hospital for diagnosis through standardized examination and then take appropriate treatment measures to control the disease.