Patients with aplastic anemia who have a fever should be seen in the hospital quickly, because aplastic anemia patients have reduced white blood cells and lack of immunity, and mild inflammation may develop into more severe inflammation or even sepsis, which is life-threatening. When patients with aplastic anemia go to the hospital, they should first have blood cell analysis, C-reactive protein and other tests to clarify the severity of the disease, so that antibiotics can be given empirically to control inflammation quickly according to the severity of the disease, while actively searching for the pathogenic basis to target the medication. Therefore, most of the fever in patients with aplastic anemia is dominated by gram-negative bacilli, and they should be given triple cephalosporin or carbapenem antibiotics, especially high-grade antibiotics to rapidly control inflammation and prevent the development of bacteraemia and sepsis that may endanger their lives. In addition, patients with aplastic anemia should eat less cold and stimulating food when they have fever, because the immunity of the intestine is reduced at this time and eating unclean food will aggravate the inflammation. Therefore, patients with aplastic anemia who have fever should first go to the hospital for active anti-inflammatory treatment.