Generalized weakness with interferon is usually caused by an adverse reaction to interferon and usually does not require special treatment. Interferon is a class of glycoprotein with antiviral, cell proliferation inhibition, immune regulation and anti-tumor effects. It is suitable for acute and chronic viral hepatitis C, chronic active hepatitis B. Some adverse reactions may occur after interferon injection, and specific interferon adverse reactions include fever, fatigue, myalgia, headache and other flu-like symptoms. Therefore, generalized weakness after interferon injection may be caused by interferon adverse reactions. Generally can not do special treatment, drink more water, pay attention to rest, enhance nutrition will slowly return to normal. It is recommended that after the injection of interferon, patients pay attention to observe their own situation, under the guidance of the doctor to adjust the drug and so on to prevent the occurrence of adverse reactions. In addition, we can not rule out other causes of generalized weakness, if the interferon injection after the discomfort, need to consult a doctor in time.