Very Early Onset Inflammatory Bowel Disease (VOIBD) cannot be cured, only palliated. Very Early Onset Inflammatory Bowel Disease (VOIBD) is characterized by a high prevalence, high disability rate, high risk of cancer, low cure rate and low age of onset. Very Early Onset Inflammatory Bowel Disease (VEIBD) is defined as inflammatory bowel disease under the age of 6 years and is associated with genetic, dietary, immunologic, and infectious factors, with genetic factors being more relevant. Children may have diarrhea, abdominal pain, mucus stools, growth retardation, etc. Pharmacological treatments, such as mesalazine and methylprednisolone; surgical treatments, such as subtotal colonic resection and ileostomy; and hematopoietic stem cell transplantation may be considered. For the treatment of very early-onset inflammatory bowel disease, it is recommended to consult a doctor for an individualized plan.