There are systemic and topical treatments for cold and sore nose relief. Strictly follow the doctor’s instructions to standardize the treatment. 1. Systemic treatment: You can take cold and flu granules or compound aminophenolamine capsules to relieve sore nose. If accompanied by severe runny nose, it suggests that there may be a combination of bacterial infection, and antibiotics, such as amoxicillin, can be used to relieve sore nose after cold after a clear diagnosis. 2. Local treatment: If the nose is sore after a simple cold, you can apply hot compresses on the nose to promote blood circulation, and rinse the nasal cavity with physiological saline, or spray the nose with physiological saline. If accompanied by recurrent runny nose, sneezing, etc., you can use loratadine, or pseudoephedrine drops, or mometasone furoate nasal spray, etc., to alleviate the discomfort of the sore nose. Therefore, it is recommended to consult a doctor in time to clarify the treatment of the cold and sore nose, not blindly diagnosed and treated.