It is usually good to be leukemia fusion gene negative. 1. A positive leukemia fusion gene usually indicates a chromosomal abnormality, and the protein formed by the fusion gene is usually a leukemia marker. When a leukemia fusion gene is positive, it usually means that it has not been cured and treatment needs to be continued. Positive to negative during chemotherapy is one of the signs that the chemotherapy is effective, and usually a period of consolidation is needed after the conversion. 2. Generally speaking, the survival of leukemia fusion-negative patients is longer than that of leukemia fusion-positive patients, but there are exceptions, for example, patients with chronic granulocytic leukemia are mostly fusion-positive. In general, it is better to be leukemia fusion negative than positive. Once leukemia occurs, you should go to a regular hospital in time and be treated under the guidance of your doctor.