Lower limb weakness after portal vein shunt surgery for liver cirrhosis may be related to neurological injury, hepatic myelopathy and other factors. 1. Nervous system injury: if the nervous system is damaged by portal vein shunt surgery for liver cirrhosis, numbness and weakness of both lower limbs and dyskinesia may occur, which is a sequela of the surgery. 2. Hepatic myelopathy: it is mostly seen in chronic liver disease or damage to the conotruncal bundle of the spinal cord after portal vein shunt surgery, which results in abnormal muscle tone of the lower limbs, manifesting as unsteady gait, stiffness and weakness of the lower limbs, movement disorder, or even developing into paraplegia. 3. Hepatic encephalopathy: there is a possibility of hepatic encephalopathy after portal vein shunt surgery. There may be other reasons for lower limb weakness after portal vein shunt surgery for liver cirrhosis. It is recommended to consult the doctor in time, clarify the reasons under the doctor’s guidance, and target the treatment and management.