Difficulty in handwriting can be caused by physiologic factors or by diseases such as cervical spondylosis, carpal tunnel syndrome, Parkinson’s disease, etc. Specific need to be based on the cause of the appropriate treatment. 1. Physiological factors: Keeping the same position for a long time or arm pressure may cause difficulty in writing, it is recommended to move the arm appropriately to avoid prolonged pressure and other situations. 2. Cervical spondylosis: Spinal cervical spondylosis will directly involve the upper limbs, making it impossible for the hand to complete fine movements such as writing, which can be alleviated through traction, acupuncture, massage and other methods. For more serious cases, surgery can be performed, such as posterior approach surgery, posterior-anterior joint approach surgery, and so on. 3. Carpal Tunnel Syndrome: The median nerve is compressed, which will involve the thumb, finger, middle finger and other fingers, causing numbness or pain at the end of the fingers, and unable to perform fine movements. It can be treated with closed treatment to reduce the congestion and edema of the nerve, and can be treated with low-dose laser, ultrasonic, ultrashort-wave and other physical therapies. In addition Parkinson’s disease can also lead to hand writing difficulties, can use amantadine, entacapone bisdopa tablets and other medications to relieve symptoms. Difficulty in handwriting, should promptly seek medical attention to clarify the cause of the disease, under the guidance of the doctor for cause-specific treatment.