For highly differentiated squamous cell carcinoma of maxillary sinus, surgical resection of the primary lesion is recommended. Meanwhile, radiotherapy and chemotherapy are needed to control the spread and proliferation of cancer cells after surgery. 1. Surgical resection: As highly differentiated squamous cell carcinoma of maxillary sinus is a tumor with high malignant degree, surgical resection is recommended immediately after its appearance, which can effectively remove the primary lesion and reduce the chance of its metastasis or spread. The specific scope of surgical resection depends on the size of the tumor and whether it infiltrates the surrounding lymphatic and connective tissues, and the first surgery should be done to remove all the tumor as far as possible. 2. Radiotherapy: radiotherapy refers to the use of radiation to destroy and kill tumor cells. Chemotherapy refers to the application of anti-tumor drugs to effectively inhibit tumor cells. Both of them can be used before and after surgical resection so as to control the growth of cancer cells and can effectively consolidate the efficacy of surgical resection, but the treatment needs to be carried out under the guidance of doctors. For highly differentiated squamous cell carcinoma of maxillary sinus, it is recommended to perform surgical resection as early as possible, which can effectively avoid distant metastasis or spreading, thus affecting the healthy life span. Meanwhile, when choosing chemotherapy drugs, one should follow the doctor’s instruction and do not take the drugs on one’s own.