Clinically there is no strong antipruritic ointment, the general patient in the symptoms of itchy skin, need to comply with the doctor’s instructions for local medication and systemic medication. 1. Local medication: usually for inflammatory skin diseases caused by itching, patients need to follow the doctor’s instructions for external use of hydrocortisone butyrate ointment, mometasone furoate ointment and other glucocorticoid medication. For limited itching, patients can use capsaicin under the guidance of the doctor. If the patient’s itching symptoms are more serious, can also use 1% or 2.5% lidocaine, bupivacaine cream and other local anesthetic treatment. At the same time, the patient also need to match the topical benadryl, doxepin and other antihistamines. 2. Systemic medication: Usually patients with generalized itching can be treated with antihistamines such as loratadine and cetirizine as prescribed by the doctor. If the itch is secondary to chronic urticaria, atopic dermatitis and cholestasis, then naloxone, naltrexone and other opioid μ-receptor antagonists can also be used. Some patients may also be treated with opioid receptor agonists such as buprenorphine and nafurafine. Meanwhile, some patients may also be treated with antiepileptic drugs such as gabapentin and pregabalin or immunosuppressants such as cyclosporine and azathioprine, depending on the cause of the disease. It is recommended that patients with symptoms of itchy skin, timely according to their own situation, under the guidance of the doctor to choose a reasonable drug treatment.