Omeprazole usually does not affect the quality of sperm, and after fertilization usually does not affect the growth and development of the fetus, so men taking Omeprazole is generally not harmful to the preparation for pregnancy. Omeprazole belongs to the proton pump inhibitors, can inhibit the secretion of gastric acid to protect the gastric mucosa, relieve the excessive secretion of gastric acid caused by stomach burning, pain and other symptoms, usually used for people suffering from gastritis, gastric ulcer and other gastric diseases. Omeprazole for its allergy and infants and young children can not be used, for allergies, liver insufficiency, pregnancy, breastfeeding women’s crowd should be used with caution under the guidance of a doctor. Adverse reactions such as headache, nausea, vomiting, constipation, abdominal pain, abdominal distension, abdominal pain, drowsiness, fatigue, rash, itching, urticaria, liver function abnormalities and other adverse reactions may occur after application. Although omeprazole has no effect on sperm quality, from the point of view of eugenics, it is advisable to discontinue the use of this drug for at least one week before preparing for pregnancy.