Whether a bone marrow puncture is painful or not depends on the situation and cannot be generalized. If it is a bone tumor, such as myeloma itself will be painful, and then puncture is performed at this time, pain will also occur. However, bone marrow puncture usually requires local anesthesia, and if this anesthesia is adequate and good, the pain is usually mild, but when bone marrow is drawn, soreness will occur regardless of the type of anesthesia, only the degree of pain is different. If the bone marrow puncture site is located in the location of a bone tumor, such as in patients with bone tumors, very severe pain may occur. If the doctor operating the procedure does not have good local anesthesia, then the patient will feel more pain during the bone marrow puncture. There are also some patients with different pain tolerance, so each situation is not exactly the same.