The choice of oral medication for patients with pyelonephritis depends on their own situation, and there is no such thing as the first choice of oral medication. The commonly used oral drugs for pyelonephritis generally include ofloxacin capsules, amoxicillin capsules, cefuroxime tablets, ampicillin tablets and so on. 1. Ofloxacin capsules: generally used for the treatment of genitourinary infections caused by sensitive bacteria, gastrointestinal infections, etc., can also be used for the anti-infection treatment of acute pyelonephritis. Adverse reactions such as abdominal pain, nausea, skin rash may occur after use of the drug, it is recommended to follow the doctor’s instructions for use, and allergy-prone people should be used with caution. 2. Amoxicillin capsule: commonly used in the treatment of upper and lower respiratory tract infections, genitourinary tract infections, can also be used for the anti-infective treatment of pyelonephritis caused by sensitive bacteria. Nausea, vomiting and other side effects may occur after use, penicillin allergy and penicillin skin test positive patients should be used with caution. 3. Cefuroxime Tablets: generally used in the treatment of upper and lower respiratory tract infections caused by sensitive bacteria, urinary tract infections, such as pyelonephritis. There may be erythema, fever, itching and other adverse reactions after use, and should be used with caution by those who are prone to allergy. 4. Ampicillin Tablets: commonly used in the treatment of respiratory tract infections caused by sensitive pathogens, urinary tract infections, such as pyelonephritis. After using the drug may have tongue inflammation, gastritis and other side effects, allergy should be used with caution. All the above medications should be used under the guidance of a doctor, avoid self-medication. Patients with pyelonephritis are advised to go to regular hospitals for timely consultation and targeted treatment or therapy under the guidance of a doctor.