For example, chronic active hepatitis, especially cirrhosis, can lead to a decrease in platelets. This is because poor liver function affects the hematopoiesis of the bone marrow system, and the production of megakaryocytes in the bone marrow is impaired, which ultimately affects platelet production. In addition, cirrhosis is often combined with splenomegaly and hypersplenism, and the enlarged spleen will engulf and destroy the blood flowing through it, which will also destroy platelets and cause a decrease in platelets. However, it should be noted that not all liver diseases will cause platelet reduction, and platelet reduction is not always caused by liver diseases.