The third dose of the vaccine generally refers to the third dose of the New Crown vaccine. The third dose of the New Crown vaccine is generally acceptable for thyroid nodules, but it is not recommended if there are obvious symptoms of hyperthyroidism or hypothyroidism. Currently, thyroid nodules are not among the contraindications for the new crown vaccine, and there is no clinical evidence that the vaccine will have an adverse effect on thyroid nodules, so the third injection of the new crown vaccine is generally allowed. However, if the patient has obvious symptoms of hyperthyroidism or hypothyroidism, it is not recommended to receive the new crown vaccine, and can wait until the condition is stabilized before considering vaccination. Whether patients with thyroid nodules can receive the third dose of the New Crown Vaccine can be decided by a specialist doctor in the Department of Endocrinology after evaluation. It is recommended that patients should be closely observed in the observation room for thirty minutes after receiving the New Crown Vaccine, and should consult a doctor for examination if there is any redness, swelling and itching at the site of vaccination, dizziness, headache, or elevated body temperature.