The severity of a spleen 52mm thick and 153mm long depends on the etiology. Splenomegaly is considered when the spleen is 52mm thick and 153mm long. Generally the cause of splenomegaly is common in infections, bruises, blood diseases and so on. 1. Infection: including viral infection, bacterial infection, malaria, schistosomiasis, etc. With active anti-infection treatment, the enlarged spleen can return to normal. 2. Siltation: commonly found in various kinds of liver cirrhosis, as well as portal vein hypertension caused by portal phlebitis, splenic phlebitis, thrombosis, etc., which leads to splenomegaly, hypersplenism can occur, anemia, infection and bleeding tendency, then the condition is more serious. 3. Blood diseases: such as chronic leukemia, chronic hemolytic anemia, myelofibrosis, etc. can cause splenomegaly, and the severity of the condition depends on the primary disease. If you find splenomegaly, you need to go to the hospital to improve the examination to clarify the cause of the disease and give targeted treatment.