If creatinine becomes high after taking entecavir, it is usually caused by impaired renal function. At this time, it is necessary to clarify whether it is caused by the drug or the disease itself, and it is necessary to firstly, stop entecavir and change to other antiviral drugs if the condition permits; and secondly, to monitor the change of creatinine in the blood, and if the creatinine is still progressively increasing, it is necessary to improve the renal puncture biopsy, so as to clarify the condition of the disease. Firstly, it should be clarified whether the creatinine increase is caused by the drugs, then entecavir should be stopped and the creatinine change should be closely observed. In order to control the disease, other antiviral drugs should be replaced under the guidance of the physician. Secondly, the creatinine changes should be closely monitored, if the creatinine rises, it is necessary to improve the renal puncture biopsy, to clarify the cause of creatinine rise, and then according to the cause of the targeted treatment. In addition, dietary attention should be paid to low-salt, low-fat, high-quality protein diet, careful use of nephrotoxic drugs, pay attention to rest, avoid exertion. After taking entecavir, creatinine becomes high, it is recommended that the patient consult a regular hospital in a timely manner, under the guidance of a physician to standardize the examination and treatment.