Morphine is a strong opioid, and drugs with similar effects include oxycodone, fentanyl and methadone, but such drugs must be used under the supervision of a clinician. Opioid painkillers such as morphine are key pain medications in the treatment of pain such as cancer pain and are the focus of the World Health Organization’s three-step pain management principles. Morphine is the standard medication for the treatment of severe pain. Morphine analgesia does not affect consciousness and other sensations at the same time, and in addition to its analgesic effect, it can also reduce emotional reactions such as anxiety and tension caused by pain. Opioids with similar effects to morphine include oxycodone, a pure opioid agonist; fentanyl, which can be administered via the mucous membranes or skin; methadone, which has a strong effect on neuropathic pain; pethidine, which is used for the short-term treatment of acute pain; and codeine, which is a weak opioid. However, it should be noted that the above drugs are nationally controlled drugs, absolutely prohibit the private sale and use, the use of the above drugs need to be under the supervision and guidance of clinicians.