In general, blister-like granules on the vulvar skin may be caused by vulvar inflammation, vulvar folliculitis, etc. They can be treated by using medication and improving daily habits. 1. Vulvar inflammation: Normally, women’s vaginal secretions are acidic, but due to external bacterial infections that change the pH of the vagina, vulvar inflammation is caused. Vulvovaginal inflammation is usually characterized by itching, redness and swelling of the vulvar skin, and in severe cases, burning or pain, blister-like granules, etc. The patient needs to go to the hospital for examination. Patients need to go to the hospital for examination, can be under the guidance of the doctor, topical antifungal cream, such as miconazole, clotrimazole, etc., can also be taken orally tinidazole, metronidazole and other drugs for treatment. 2. Vulvar folliculitis: it refers to purulent skin inflammation of the vulva caused by bacterial infection, usually manifested as redness, swelling and pain in the follicular opening of the vulvar skin, and in the later stage of severe cases, it may develop into small blister-like particles or papular pustules. Patients can be treated by local topical application of drugs under the guidance of doctors, such as fusidic acid cream, mupirocin ointment and other drugs, and oral medications, such as doxycycline, minocycline and other treatments can be considered as appropriate according to the degree of infection. Patients should pay attention to the dryness and cleanliness of the local skin. Patients need to keep their underwear breathable and clean, pay attention to the dryness and cleanliness of the local skin, do not eat spicy and irritating food, and do not scratch with their hands to prevent the symptoms from worsening. It is recommended that patients consult a doctor in a timely manner and standardize the treatment under the guidance of the doctor.