Enlarged breast nuclei in 60-year-old men are usually related to endocrine disorders, subcutaneous lipoma, breast hyperplasia and other factors. 1. Endocrine disorders: for example, an increase in estrogen level, a decrease in androgen level, a decrease in testosterone level, etc. in men may cause breast nucleus enlargement. 2. Subcutaneous lipoma: it may be related to obesity, when localized lipoma appears, the enlargement of the tumor may cause the breast nucleus to become bigger. 3. Breast dysplasia: mostly seen in puberty, in puberty is mostly physiological factors, while at present 60 years old men should be alerted to be caused by pathological factors, such as breast hemangioma, lymphoma and so on. If the 60-year-old man appeared breast nucleus enlargement, may also be other reasons, it is recommended to timely medical treatment, and then through the breast ultrasound for preliminary diagnostic analysis, it is also necessary to check the sex hormones, to understand whether the hormone level is disturbed, and then according to the diagnostic results of the targeted treatment.