Vocal fold granuloma can be treated with glucocorticoid drugs such as prednisone in the early stage; if the granuloma is large or accompanied by surface erosion, surgical treatment is needed. Vocal fold granuloma at the initial stage will be manifested as mucosal edema and erosion on the surface of the new organisms, which can be treated with anti-inflammatory and anti-swelling glucocorticoid drugs, such as prednisone and budesonide. If accompanied by gastroesophageal reflux and other phenomena, you can use omeprazole and other acid-suppressing drugs to control reflux phenomena, to reduce the mucosa of the vocal folds stimulated by gastric acid. If the granuloma is large or accompanied by surface erosion, it can be treated by surgical resection, and the pathology should be clear whether there is malignant phenomenon after surgery. If malignant lesions have already appeared, it is necessary to expand the scope of the lesion again surgical excision treatment. Vocal granuloma, need to go to the otorhinolaryngology, clear condition, follow the doctor’s instructions for treatment.