Pediatric hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus infection and can be divided into mild and severe forms. Mild hand, foot and mouth disease is the most common, in the beginning of the disease can have fever, anorexia, most of the rash in the onset of the day or the next day, no itchy, most of the distribution of the rash in the limbs, oral mucous membranes, around the anus and perineum, the herpes can be broken out, there is a certain degree of contagiousness, the whole course of the disease is about 7-10 days, the prognosis is good. Severe hand, foot and mouth disease in addition to the above manifestations, can be manifested as a persistent high fever does not go away, depression, shallow, fast breathing, rapid heart rate, peripheral circulation, hyperglycemia, etc. If the above manifestations, it is suggestive of a severe disease, the need for timely access to hospitals and take the necessary treatment measures.