The time for hypertensive patients to take antihypertensive drugs depends on the pattern of blood pressure fluctuations and the characteristics of the drugs chosen. Under normal circumstances, human blood pressure has two peaks in a day, the first peak is nine to eleven in the morning, the second peak is four to six in the afternoon, from six in the afternoon began to slowly decline, to the next morning at two to three in the lowest. According to the law of blood pressure changes to choose the time to take medication: a day to take one antihypertensive drugs (including controlled-release tablets and slow-release tablets) more in the morning at seven o’clock; two times a day to take antihypertensive drugs, at seven o’clock in the morning and two o’clock in the afternoon. There is a special situation, some hypertensive patients’ blood pressure fluctuations are not in accordance with this rule, the blood pressure is higher during the day, and the blood pressure does not decrease at night, that is to say, it belongs to the night hypertension, this time it is necessary to adjust the time of taking antihypertensive drugs In this case, it is necessary to adjust the time of taking antihypertensive drugs, you can take antihypertensive drugs once before going to bed. In addition, the timing of the medication and the influence of other factors may vary from drug to drug. In general, long-acting antihypertensive drugs should be taken only once a day, within half an hour or an hour after waking up in the early morning; short-acting antihypertensive drugs should be taken twice a day (once in the morning and once in the evening) depending on blood pressure. The international treatment protocol gives priority to the use of long-acting preparations, which can last for 24 hours with only one dose per day, providing good control of nighttime and morning peak blood pressure and effective prevention of cardiovascular and cerebrovascular complications. The pattern of blood pressure fluctuations can be clarified by doing 24-hour ambulatory blood pressure testing. Before taking antihypertensive drugs, it is important to read the drug instructions carefully and choose the right time to take the drug according to the fluctuation of individual blood pressure.