Hypertension medication is generally best taken in the morning on an empty stomach, that is, after waking up in the morning and before breakfast. The reason is that the current antihypertensive drugs are generally long-acting antihypertensive drugs, including various controlled-release tablets and slow-release tablets. The duration of drug action is relatively long, and some can even be maintained for 24 h. Taking them in the morning on an empty stomach can make the peak of blood concentration, maintained in the morning and afternoon. Under normal human conditions, the lowest blood pressure period occurs in the early hours of the night. If the antihypertensive drug is taken too late, together with the appearance of the lowest blood pressure in the body, it can lead to nighttime hypotension so that the morning peak hypertension in the morning of the 2nd day can occur. Taking antihypertensive drugs in the morning on an empty stomach can lead to a corresponding decrease in blood concentration at night, avoiding the phenomenon of nocturnal hypotension. Therefore, antihypertensive drugs are usually taken in the morning on an empty stomach, but the time to take them varies from person to person, and appropriate adjustments can be made according to the time of day when each person’s blood pressure rises.