Nosyntho is sacubitril valsartan and can be taken as one capsule once a day for the treatment of essential hypertension, and twice a day is needed for the treatment of chronic heart failure. Sacubitril valsartan is a new type of drug for the treatment of heart failure, containing two components of sacubitril and valsartan, the organic combination of the two drugs can effectively dilate blood vessels, reduce the load on the heart, reduce the symptoms of patients with heart failure, and long-term oral intake can effectively inhibit ventricular remodeling and slow the progress of the disease. When clinically used in the treatment of essential hypertension, the usage is once a day, one capsule at a time. When used in the treatment of chronic heart failure, it is required twice a day. In the process of taking Sacubitril valsartan, it is necessary to pay attention to the monitoring of blood pressure and potassium to avoid serious adverse reactions such as hypotension and hyperkalemia, and the drug is prohibited for patients with a history of angioedema who have previously taken ACEI-type or ARB-type drugs, pregnant women, and patients with severe hepatic impairment, so the use of the drug needs to be carried out under the guidance of a professional physician.