Adapalene Gel and Azelaic Acid Cream, not normally used together. Adapalene gel and azelaic acid cream can be used in the treatment of acne, and both drugs have antibacterial activity against Propionibacterium acnes, there is no clear data between the two drugs can be used in combination, so in the treatment of acne is generally not used at the same time, need to be used separately. The main ingredient of adapalene gel is adapalene, which belongs to retinoid compounds, has the effect of dissolving keratin as well as anti-inflammatory, and is commonly used in the treatment of common type acne. The drug should not be used concurrently with other retinoids with similar mechanisms of action, as well as other drugs. Azelaic acid cream, the main component of which is azelaic acid, can kill Propionibacterium acnes by inhibiting the protein synthesis of microorganisms, and can be used for the treatment of acne vulgaris in clinical practice. The drug and other similar drugs used together, may occur mutual reaction. To ensure the safety and effectiveness of the medication, it must be taken at intervals or under the supervision of a doctor.