Mediterranean in the clinical generally refers to thalassemia, couples with mild thalassemia can have a second child. Thalassemia is a hereditary hemolytic disease, minor thalassemia usually has no obvious clinical symptoms, occasionally there will be a decline in physical strength. Therefore, couples with mild thalassemia can have a second child, but it is necessary to do a good prenatal examination, such as genetic testing, through which you can know the probability of the fetus suffering from the disease. If both husband and wife are homozygous gene carriers, the probability of the fetus suffering from thalassemia will also be relatively higher. Therefore, it is necessary to strengthen the obstetric examination during pregnancy, and amniocentesis can be carried out in the mid-pregnancy to clarify the genotype of the fetus, so as to reduce the birth rate of the newborn with the disease. If both husband and wife with thalassemia minor intend to get pregnant, they can consult the doctor in advance, prepare for pregnancy under the doctor’s guidance, and carry out relevant examinations to avoid adverse effects.