High neu-specific enolase in small lung nodules should be alerted to the possibility of cancer, and further examination is needed to exclude it. Neurtrienolase is a tumor marker, its value is high with lung nodules, there is a possibility of lung cancer, need to regularly review the chest CT, if the nodule growth rate is faster, or the edge of the nodule has burrs, related to lung cancer tumor markers increased, need to do chest enhancement CT to see whether the nodule is strengthened, such as enhancement, need to do a puncture pathology examination, to clarify the presence or absence of lung cancer. For those who have small lung nodules with high neuro-specific enolase, it is recommended to quit smoking, have regular follow-up CT to observe the changes of the nodules, listen to the doctor’s advice, and carry out standardized treatment under the doctor’s guidance.