With renal insufficiency, it is generally recommended to use ibuprofen with caution, especially in severe renal insufficiency, it is better not to take ibuprofen. Ibuprofen belongs to non-steroidal anti-inflammatory drugs, which can be used clinically to treat mild to moderate pain and relieve discomfort caused by inflammation. However, such drugs may have certain toxic side effects on the kidneys, such as interstitial nephritis, one of the common causes of interstitial nephritis is non-steroidal anti-inflammatory drugs, of course, this toxic side effect is not always happen. Therefore, patients with renal insufficiency need to use ibuprofen with caution, especially patients with severe renal failure or pre-existing renal interstitial injury should avoid using this type of drug. In addition, it is recommended to be contraindicated in patients who are allergic to non-steroidal anti-inflammatory drugs, pregnant and breastfeeding women, patients with severe hepatic insufficiency and heart failure. Patients with renal insufficiency are advised to visit the hospital in time and follow the doctor’s instructions for standardized treatment, do not self-medicate.