Gout is mostly related to purine metabolism disorders, currently can eat inhibit uric acid production and promote uric acid discharge of the drug uric acid.
Uric acid is the end product of purine metabolism, gout treatment focuses on controlling blood uric acid level. Gout patients can use drugs that inhibit uric acid production and promote uric acid discharge.
1. Inhibit uric acid production of drugs: the more commonly used drugs are febuxostat, allopurinol, the use of febuxostat adverse reactions include nausea, skin rash, liver function impairment, etc., allopurinol can appear rash, drug fever, liver enzyme elevation and other adverse reactions. Adverse drug reactions need to be closely monitored during the use of the drug.
2. Promote uric acid excretion of drugs: commonly used benzbromarone, probenecid, benzbromarone for glomerular filtration rate <20ml/(min-1.73m^2) or uric acid kidney stone patients are prohibited, the adverse reactions of the drug are gastrointestinal discomfort, diarrhea, skin rash. Probenecid is contraindicated in those who are allergic to sulfonamide.
Gout patients are advised to go to the rheumatology and immunology department of regular hospitals and other related departments in a timely manner, and follow the doctor's instructions for medication.