The prognosis for duodenal bulb ulcers is generally good and does not affect normal life expectancy. However, if combined with serious complications, survival time may be affected. A duodenal bulb ulcer is a tissue injury located in the intestinal wall of the duodenal bulb that exceeds the mucosal muscle layer and is confined to a round or oval shape, manifesting as periodic epigastric pain, acid reflux, and belching. The disease is prone to recurrent attacks, occurs in spring and autumn, and is usually diagnosed clearly by gastroscopy, often in association with Helicobacter pylori infection. Complications of duodenal bulb ulcer are mostly bleeding and perforation, pyloric obstruction, and may be life-threatening in case of gastrointestinal hemorrhage or perforation of the digestive tract. Most duodenal bulb ulcers are not cancerous, and most of them can be completely cured by active cooperation with treatment. It is advisable to eat a light diet, eat less spicy and oily food, quit smoking and drinking, pay attention to abdominal warmth, adjust your mind and reduce stress.