Of the two drugs, elamod and methotrexate, because elamod has an anti-inflammatory effect, while methotrexate does not have an anti-inflammatory effect, so the anti-inflammatory effect of elamod is a little better. 1. Elamod can inhibit the production of inflammatory cytokines (interleukin-1, interleukin-6, interleukin-8, tumor necrosis factor alpha) and immunoglobulin; it has anti-inflammatory effect. The drug is indicated for active rheumatoid arthritis. Elamod can cause adverse reactions such as erythrocytopenia, leukopenia, and hepatotoxicity. It is often contraindicated in pregnant women, women with likelihood of pregnancy, patients with severe liver disease, patients with peptic ulcers, or those with a previous history of peptic ulcers. Precautions: Since the efficacy and safety of combination with antirheumatic drugs other than methotrexate have not been clarified, special attention should be paid to the clinical observation of the combination of drugs. 2. Methotrexate can inhibit DNA biosynthesis and has no anti-inflammatory effect. Methotrexate can be used in various types of acute leukemia, malignant lymphoma, multiple myelopathy; head and neck cancer, lung cancer, psoriasis; breast cancer, cervical cancer and so on. Methotrexate can cause adverse reactions such as amenorrhea and sperm reduction or deficiency. It is contraindicated in patients with a known high degree of hypersensitivity to the product. CAUTION: After prolonged use, there is a potential risk of secondary tumors. Both elamod and methotrexate are anti-rheumatic drugs, but elamod has anti-inflammatory effects while methotrexate does not, making elamod more effective in combating inflammation. Elamod and methotrexate are recommended to be used under the supervision of a physician.