A first-born albino second-born can be checked. The second child with albinism in the first pregnancy can be detected by extracting chorionic villi and amniotic fluid for fetal DNA testing to find out if there are any mutated loci from the father’s or mother’s genes, and the fetal DNA is the same as that of the first-born albino child, which usually identifies the fetus as a child with albinism. The second fetus with albinism can also be fetoscoped at 20 to 24 weeks of gestation to observe the color of the fetal skin and hair. Fetal hair and skin that is white and light in color has a higher likelihood of having albinism. Pregnant women with malpositioned fetuses or placenta praevia should not undergo the test. Couples who have had a child with albinism should undergo prenatal genetic testing as soon as possible. Albinism is a single gene autosomal recessive disease, which is a hereditary disease caused by a congenital deficiency of tyrosinase, or tyrosinase hypoplasia, resulting in impaired melanin synthesis. Couples who have a child with albinism should undergo genetic testing as early as possible and prohibit consanguineous marriages in order to prevent the fetus from suffering from the congenital disease.