Amyloidosis is a clinical syndrome in which amyloid is deposited between the cells of various organs in the body due to a variety of causes, resulting in progressive failure of the affected organs. Although it is a benign disease, there is still no cure and there is a high morbidity and mortality rate within a few years of diagnosis. The cause of amyloidosis is unknown and it can be hereditary or acquired. The incidence of amyloidosis is higher in women than in men, and women tend to develop the disease earlier and more severely. The common age of onset is 15 ~ 60 years. Clinical manifestations The clinical manifestations of airway amyloidosis are categorized into three types depending on the extent, degree, and location of amyloid deposition: 1. Focal amyloidosis of the upper airways, with the larynx being the most common site; and 2. Tracheobronchial amyloidosis, which is categorized into focal and diffuse. Focal amyloidosis is the most common; 3, pulmonary amyloidosis, including single, multiple, fusion nodular and alveolar septal diffuse amyloidosis. Among them, trachea-bronchial amyloidosis clinical manifestations: often subacute, manifested as progressive dyspnea, wheezing, cough, recurrent pneumonia and hemoptysis. The clinical manifestations are different according to the site of the disease. In patients with central airway involvement, the symptoms mainly manifest as airway obstructive symptoms. In moderate airway involvement, the symptoms include lobar collapse and recurrent infections, and in small terminal airway involvement, recurrent pneumonia, cough and bronchiectasis. Pleural effusion may also be present. Treatment Airway amyloidosis is a rare condition that may or may not be associated with systemic manifestations. Bronchoscopic intervention is currently the main effective treatment for bronchial amyloidosis. It is important to note that an enhanced CT scan should be performed to determine whether the granuloma is rich in blood supply, and if necessary, target arteries should be pre-interventionally embolized before bronchoscopic debulking. Bronchoscopic interventions include scleroscopic scooping, cryoablation, and stent placement. Local elimination should be considered as the mainstay of limited lesions to restore airway patency.