Treatment of heart failure in the elderly

The goals of treatment for elderly patients with heart failure are to improve symptoms and exercise tolerance, to improve quality of life, to reduce hospitalization events, to prolong life, and to save medical costs for heart failure treatment. The risk-benefit ratio and the compliance of the elderly (especially in cases of functional impairment or cognitive impairment) should be assessed for any treatment chosen. The treatment of heart failure in the elderly includes pharmacological and non-pharmacological treatments, commonly used drugs: diuretics, ACEI, ARB, receptor blockers, aldosterone receptor antagonists, digoxin, statins. Non-pharmacological treatments include: exercise training, CRT, CRT-ICD. Diuretics: Elderly patients with heart failure almost always have varying degrees of water and sodium retention, therefore, the application of diuretics is an important part of the management of heart failure in the elderly. However, the various physiological compensatory functions of the elderly are low, and more side effects will occur if they are not applied properly, so the application skills should be mastered: starting with small amounts, slow diuresis; the combination of potassium-preserving and potassium-removing diuretics, especially aldosterone receptor antagonists such as aminoglutethimide and eplerenone for the treatment of heart failure in the elderly; monitoring blood biochemical indicators; combined medication (can be combined with ACEI, β-blockers, digoxin). ACEI is the earliest proven to improve the prognosis of patients with chronic heart failure, commonly used ACEI are enalapril, benazepril, lazanopril and so on. The application of ACEI or ARB in elderly patients with heart failure can reduce mortality, especially the rate of rehospitalization due to heart failure, but the most important side effects of ACEI and ARB in elderly heart failure include hyperkalemia, aggravation of renal insufficiency and postural hypotension. Beta-blockers can improve clinical symptoms, left ventricular function, and ventricular remodeling in elderly and young patients, improve survival and reduce mortality on the basis of standard therapy, and are effective in reducing the rate of sudden death. beta-blockers with evidence of use in heart failure include metoprolol, bisoprolol, and carvedilol. The application of beta-blockers in elderly patients with heart failure should be individualized, starting with small doses and gradually adjusting the dose. Non-pharmacological treatment is mainly resynchronization therapy, which is effective in elderly patients with chronic heart failure.