Total urine protein and urine creatinine are both high but the ratio is normal, usually can’t clarify the severity of renal injury, it is recommended to further improve the 24-hour urine protein quantification and classification and renal function and other related tests, to determine the severity of the renal condition. 1. High urine protein may be due to physiological or pathological reasons, physiological reasons can be seen after strenuous exercise, and pathological reasons can be glomerular or tubular lesions. If there is no recent strenuous exercise, the 24-hour urine protein quantification is reviewed, and if it is >150mg/d, it suggests that there is renal injury. Determine the renal injury according to the urine protein classification results. (1) If the urine protein result is albumin and transferrin, consider glomerular injury. (2) If the urine protein result is α1-microglobulin or β2-microglobulin, consider renal tubular lesions. (3) If the urine protein result is immunoglobulin IgG, consider glomerular filtration membrane damage. 2. Simply high urinary creatinine value has little significance, not to exclude fast metabolism or after strenuous exercise, it is recommended to combine with renal function index analysis, such as urea nitrogen, blood creatinine, cystatin C and so on are normal, do not consider renal injury, or else consider renal lesions. If the patient found that the total urine protein and urine creatinine are high, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.