What is a “medicine pair”? In the application of herbal medicine to treat tumors, 1. the effect of single medicine is limited due to the complexity of the disease and often cannot fully take into account the complex and changing disease; 2. the power of single medicine is limited and often cannot help for those who are heavily ill; 3. drugs often have toxic and side effects, and sometimes the unit of medicine is not safe and may have adverse effects on the body, etc. Therefore, according to the different needs of different diseases and the different characteristics of drugs, two or more drugs can be selectively applied together according to certain experience. Therefore, according to the different needs of different conditions and different characteristics of drugs, according to certain experience selectively apply two or more drugs together, not only to take care of the disease; can reduce or eliminate the toxicity and side effects of drugs, so that the clinical use of drugs more effective and safer; in addition, the drug combination, but also may produce a new effect different from the original drug. The combination of two drugs can play a synergistic role to enhance the efficacy of drugs, or eliminate toxic side effects, or produce new effects, which is collectively called “drug pair” or “drug pair”. The following are several “drug pairs” for the clinical treatment of tumors: (a) Heat-clearing and detoxifying drug pairs 1. It has good effect on cancer manifesting water-dampness retention, chest fluid, ascites and loose stools. 2.Lu Ying + Bai Ying The combination of the two herbs has the effects of clearing heat and detoxifying, promoting water retention and swelling, activating blood circulation and dispelling blood stasis, dispelling wind and relieving pain, and is commonly used in the treatment of various cancers, mostly for digestive system tumors, such as liver cancer, stomach cancer, intestinal cancer and kidney cancer, which are characterized by natural toxic stasis and water-damp internal stagnation. It is especially effective for those with cancerous pleural fluid and ascites. 3.Serpentis alba + Semen lotus The combination of the two drugs can not only clear heat and detoxify, but also reduce dampness and swelling; it is effective for redness, swelling, heat and pain of damp-heat stagnant meridians and joints, unfavorable flexion and extension, redness and pain of throat, etc. In addition, the combination of the two has the function of anti-tumor and inhibition of cancer cell proliferation. It is often used clinically to treat various cancers, such as liver cancer, stomach cancer, intestinal cancer, kidney cancer and other cancers caused by heat and toxic stagnation and internal stagnation of water and dampness. It has certain therapeutic effect on those with cancerous chest and ascites. 4.Half Lotus+Seven-leaved One-branch Flower The combination of the two has the functions of clearing heat and detoxifying, promoting blood circulation and dispelling blood stasis, dispelling wind and relieving pain, which is clinically used in the treatment of many kinds of cancer, especially for digestive system tumors, such as liver cancer, stomach cancer, pancreatic cancer, intestinal cancer and kidney cancer, which belong to heat and toxin stasis and water-damp internal stagnation. It is especially effective in treating cancerous chest and ascites. 5.Fishy grass+Xiaquan Cao The two are used together to clear heat and detoxify, drain pus and eliminate carbuncles, dissolve phlegm and disperse nodules, which are commonly used in the treatment of esophageal cancer, stomach cancer, cervical cancer, breast cancer and thyroid cancer. 6.Shijiazhuang+Hanbianlian The combination of the two works together to clear heat and detoxify, dispel blood stasis and nodules, reduce swelling and resolve phlegm, and is commonly used clinically to treat tumors of the digestive system and urinary system, such as esophageal cancer, gastric cancer, pancreatic cancer, bladder cancer, prostate cancer, etc. 7.Half Lotus+Longan The combination of the two has the function of clearing heat and detoxifying, activating blood circulation and promoting water circulation to reduce swelling, which is commonly used in the treatment of various cancers, especially for digestive system tumors, such as liver cancer, stomach cancer, pancreatic cancer, intestinal cancer, kidney cancer, leukemia, etc., which are caused by heat and toxin stasis and water-dampness internal stagnation. It is especially effective for cancerous thoracic ascites. 8.Bitter’s ginseng + Fu Ling The combination of the two can enhance the function of clearing heat, detoxifying and removing dampness, which is often used in urinary tumors with damp-heat injection, hot and stinging urine. 9, old stork grass + luo shi vine two together, mutual use, pungent open bitter down not only play the anti-tumor effect, but also has a good effect of dispelling wind and relieving pain, commonly used clinically in the treatment of breast cancer and cancer pain. 10.Half of the lotus + seven-leaved one branch of the flower The combination of the two with pungent, open and bitter, together can clear heat and detoxify, promote blood circulation, relieve swelling and pain, calm the wind and calm the panic, and is used clinically for many kinds of tumors, such as brain tumors, lung cancer, liver cancer, bladder cancer, leukemia, lymphoma and other heat poison stasis. The modern anti-cancer preparation “Lotus Tablet” is processed with this “medicine pair” as the main ingredient. 11.Leucospermum + Dilong The combination of the two works together to clear heat and detoxify, invigorate blood, eliminate carbuncles and open the veins, and is commonly used clinically in the treatment of breast cancer, liver cancer, pancreatic cancer, malignant lymphoma, leukemia and other cancerous tumors with heat and blood stasis. 12.Dong Ling Cao+Wei Ling Xian The combination of the two works to promote blood stasis and lower qi, soften hardness and disperse knots, invigorate blood and subdue swelling, which is often used in the treatment of esophageal cancer, pancreatic cancer, gastric cancer and other digestive system tumors due to phlegm, stasis and heat toxicity. 13.Shaogan+Seven-leaved One-branch Flower The combination of the two can help clear heat and detoxify, eliminate phlegm and throat, reduce swelling and pain, and is often used in the treatment of nasopharyngeal cancer and laryngeal cancer. 14.Half of a branch of lotus + white mustard seeds, the combination of cold and warm, can clear heat and detoxify and can be used for a variety of tumors caused by phlegm, dampness, poison and paralysis. 15.Shijiazhuang+Gecko The combination of the two can remove blood stasis, detoxify and disperse nodules, reduce swelling and resolve phlegm, which is commonly used in the treatment of esophageal cancer, nasopharyngeal cancer, lung cancer, cervical cancer, skin cancer, rectal cancer, pancreatic cancer and other cancers caused by phlegm and stasis. 16.Shanci mushroom+Serpentine root The combination of the two works to clear heat and detoxify, invigorate blood circulation and eliminate blood stasis, resolve phlegm and disperse knots. It is often used in the treatment of digestive system tumors, such as esophageal cancer, cardia cancer, gastric cancer and hepatocellular carcinoma with mutual stagnation of phlegm and stasis. (2), the spleen and permeate the damp medicine pair 1, Poria + pig ling two together must be used, water to strengthen the spleen anti-tumor power to enhance the treatment of digestive system tumors, clinically can be used to identify the symptoms. Modern research suggests that Poria and Poria have obvious diuretic effect, the mechanism of action is mainly to inhibit the renal tubular reabsorption of water and electrolytes, so it can be used in the treatment of cancerous thoracic ascites. 2.Coix seeds + Poria cocos, the combination of the two play a role in strengthening the spleen and permeating dampness, drainage of water and pus, which is often used clinically for digestive system tumors, such as liver cancer, stomach cancer, intestinal cancer, pancreatic cancer, etc. In addition, the combination of the two has the function of anti-tumor and inhibiting the proliferation of cancer cells, which is clinically used in the treatment of various cancers, especially for digestive system tumors, such as liver cancer, stomach cancer, intestinal cancer, kidney cancer, etc., which are caused by heat and toxin stasis and water-dampness internal stagnation. It is especially good for cancerous thoracic ascites. 4.Coix seeds+Ume plum are used in combination with each other to exert the effect of dispersing and eliminating tumors. It is often used clinically for treating uterine fibroids, ovarian cysts, pelvic inflammatory masses, gastrointestinal tumors, etc. (3), softening phlegm and dispersing nodules 1, Shou Gong + White Flower Snake The combination of the two is used to dispel the wind and calm the fear, detoxify and disperse nodules, and relieve pain. Modern anti-cancer preparation “Golden Dragon Capsule” is made of this “medicine pair” as the main ingredient. 2.Shanci mushroom + Crow’s gall bladder The combination of cold and heat can help clear heat and detoxify, dissolve phlegm and disperse nodules, which is commonly used in clinical treatment of esophageal cancer, stomach cancer, intestinal cancer, liver cancer, lung cancer, cervical cancer, tumors of the five senses and other tumors with heat and toxicity. The modern anti-cancer preparation “Cidan capsule” is processed with this “medicine pair” as the main component. 3.Shanci mushroom + Curcuma zedoaria The combination of the two is pungent and bitter, which can clear heat and detoxify, dissolve phlegm and disperse nodules, and is commonly used in the treatment of liver cancer, stomach cancer, esophageal cancer, cervical cancer, skin cancer, bone sarcoma and other patients with heat and toxic stagnation of Qi and blood. Modern anti-cancer preparations “Cidan Capsules” and “Lotus Tablets” are made by processing this “medicine pair” as the main component. 4. Raw oyster + Xia Gu Cao The combination of the two works together to pacify liver and submerge yang, resolve phlegm, soften hardness and disperse nodules. It is often used clinically for the treatment of breast tumor, liver cancer and other tumors with liver depression and phlegm-fire stagnation. The modern anti-cancer preparation “Breast Health Tablet” is processed with this “medicine pair” as the main component. 5.Leucorrhoea + Cichlid mushroom The combination of the two can clear heat and detoxify, resolve phlegm, eliminate carbuncles and disperse nodules, which is often used clinically for the treatment of liver cancer, pancreatic cancer, malignant lymphoma, breast cancer, leukemia, tongue cancer and other tumors with heat and toxic congestion. The modern anti-cancer preparation “Breast Nucleus Dispersing Tablet” is made of this “medicine pair” as the main ingredient. 6.Acute seeds+Wei Ling Xian The combination of the two works together to move blood stasis and lower qi, soften hardness and disperse knots, and relieve pain, which is often used clinically in the treatment of digestive system tumors such as esophageal cancer, cardia cancer, gastric cancer and other tumors with mutual knots of phlegm and stasis. 7.Turtle shell + Impatiens Modern pharmacological research shows that: turtle shell has the effect of inhibiting respiration on human type liver cancer and stomach cancer cells; it has inhibitory activity on liver cancer, stomach cancer and acute lymphoid leukemia cells. In addition, it can increase plasma protein, can promote hematopoiesis, can inhibit connective tissue proliferation, and can eliminate lumps. Andrographis paniculata has anti-leukemic effect and has the effect of elevating white blood cells. In combination, the two are often used clinically on the basis of dialectical evidence for the treatment of hepatosplenomegaly, hepatocellular carcinoma, pancreatic cancer, gastric cancer and leukemia, and have a certain ameliorating effect on the malignant tumor’s malignancy. The combination of the two, specifically entering the liver meridian and reaching the lesser abdomen, is beneficial in dispelling cold and pain, dispersing nodules and eliminating swelling, and can be used clinically for testicular tumors, breast tumors and intra-abdominal masses, etc. 9. Centipede + White Mustard Seed is good at searching wind and cleaning phlegm, and is effective in treating difficult chronic diseases and masses in the abdomen. It is suitable for tumors of digestive system, which are characterized by abdominal masses in the abdomen, with pain at a certain place, which do not heal over a long period of time, damage to positive qi, agglutination of qi and blood, blood clotting as stasis, stagnation of qi and dampness without transforming phlegm, and mutual entanglement of phlegm and stasis, forming masses in the Y obstruction. 10.Rhubarb+Earthworm (Stinging Worm, Ground Turtle Worm) The combination of the two is described in “Rhubarb Stinging Worm Pill” in Zhang Zhongjing’s “Essentials of the Golden Horoscope”. The combination of the two is used for the meaning of “pass to remove the blockage and the worm to move the stasis”, and is often made into honey pills, which are used for the meaning of “dull medicine and slow attack”. Clinically used in the treatment of uterine fibroids, cervical cancer, etc., and the symptoms are abdominal masses, purple tongue or stasis spots, thin and astringent pulse. 11.Panax notoginseng + Saponaria sp. The combination of the two is often used clinically for the treatment of breast cancer, cervical cancer, intestinal cancer, nasopharyngeal cancer, etc. with phlegm coagulation and stagnation. (4) Blood-stasis management medicine pair 1.San Ling + Curcuma longa The combination of the two is used to activate blood circulation and resolve blood stasis, move Qi to relieve pain, resolve accumulation and eliminate lumps. It is commonly used in the treatment of liver cancer, osteosarcoma, stomach cancer, esophageal cancer, cervical cancer, skin cancer and other cancers with Qi and Blood stagnation. 2.Serpentis alba+Small thistle, in combination, can clear heat and detoxify, invigorate blood circulation and eliminate blood stasis, induce diuresis and laxative, cool blood and stop bleeding. It is commonly used in the treatment of urinary tumors, such as bladder cancer, kidney cancer, prostate cancer, etc. 3. Panax ginseng + Curcuma zedoaria is used in combination to promote the flow of qi, remove blood stasis, eliminate stagnation and relieve pain, and is often used in the treatment of bladder cancer, cervical cancer, liver cancer, stomach cancer and other cancers caused by qi stagnation and blood stasis. It is also commonly used to treat pain in the limbs or internal organs caused by various cancerous tumors. 4.Earthworm + Silkworm The two are used together to break blood stasis and remove phlegm and disperse knots. They are often used clinically to treat brain tumors, esophageal cancer, stomach cancer, lung cancer, liver cancer, laryngeal cancer, malignant lymphoma and other cancers with mutual knots of phlegm and heat. In addition, the combination of two “drug pairs”, Tu-Yuan + Silkworm and Scorpion + Centipede (attacking poison and dispersing nodules), is used for the treatment of cancer pain and has a good pain relief effect. 5, chasteberry + dried lotus herb both enter the liver and kidney meridians, is a flat tonic liver and kidney products, nourishing Yin but not greasy stagnation, must be used for each other, promote each other, tonic liver and kidney, clear deficiency heat, cool the blood to stop bleeding power enhanced. It is often used clinically for various malignant tumors with internal heat due to yin deficiency and blood flow due to blood in urine, blood in stool, blood in vomiting, epistaxis and other bleeding disorders; or leukopenia after radiotherapy for various malignant tumors. (e), support the righteousness and dispel the evil medicine pair 1, white peony + roasted licorice two used together, applicable to the detention of acute pain. The symptoms include acute pain in the abdomen and stomach, which is relieved by Gan; or acute pain in the limbs, which is relieved by pressing. It is accompanied by depression, red tongue with little coating and small string pulse. Insufficient qi and blood, lack of circulation of Ying and Wei, and loss of nourishment of the veins and ligaments, resulting in the evidence of “pain without glory” is a good match. Clinically, this “pair” is often used in combination with worm medicine to treat pain in the limbs or internal organs caused by various tumors. 2. Atractylodes macrocephala + Citrus aurantium, both of them are good at relieving abdominal distention and dampness. The symptoms include abdominal distention and distention, which is worse after eating, especially during hunger, poor appetite, belching, poor bowel movement, body fatigue and few words, light red tongue, thin moss and deficient string pulse. Commonly used clinically for gastrointestinal reflections caused by radiotherapy should. 3.ShanYu flesh + white peony The combination of the two has a synergistic effect, can enhance the anti-tumor, immunomodulatory and anti-inflammatory effects, thus has a certain therapeutic effect on malignant tumors such as liver cancer, esophageal cancer, intestinal cancer. 4. Panax ginseng + Ganoderma lucidum The combination of the two can tonify qi and blood, invigorate blood, eliminate swelling, disperse nodes and relieve pain, which is commonly used in the treatment of lung cancer, esophageal cancer, gastric cancer, liver cancer, chronic granulocytic leukemia and other malignant tumors with deficiency of qi and blood stasis or deficiency of evil. The modern anti-cancer preparation “Ginseng Tablet” is made by processing this “medicine pair” as the main ingredient. 5.Lily of the valley + fishy grass The two are used together to clear heat and detoxify, nourish yin and moisten lung, drain pus and eliminate carbuncles. It is often used clinically in the treatment of lung cancer, stomach cancer, leukemia, skin cancer and other malignant tumors with yin deficiency and heat toxin stagnation. (F), qi-relief and pain relief medicine pair 1, Yuan Hu + Xu Changqing The two are used together to promote blood circulation and eliminate blood stasis, and promote qi-relief and pain relief. It is often used clinically to treat pain in the limbs or internal organs caused by various cancerous tumors. 2.Bai Quai+Xu Changqing are used in combination to clear heat and detoxify the blood, promote blood circulation, eliminate swelling and relieve pain, which is often used in the treatment of esophageal cancer, stomach cancer, lung cancer, nasopharyngeal cancer and skin cancer caused by heat and toxic stasis. It is also commonly used to treat pain in the limbs or internal organs caused by tumors, and is indeed effective. 3.Xuanfuhua+Daixuoxing stone The combination of the two, one is declaring and the other is descending, declaring and descending legally, together with the function of heavy sedation and vomiting, resolving phlegm and eliminating gangrene, is often used clinically in the treatment of obstruction caused by gastrointestinal tumors, pylorus incomplete obstruction and other conditions. 4.Jinlingzi+Yanhuzo The combination of the two, a cold and a warm, cold and warm use; a release of qi points of depression, a line of blood stagnation, qi and blood in parallel, for the movement of qi and blood to relieve pain of common pairs of drugs. It is often used clinically to treat pain in the limbs and internal organs caused by various tumors. 5.Gao Liang Jiang+Aromatic Herb. The combination of the two disperses cold stagnation and Qi stagnation, warms the middle and disperses cold, moves Qi and drains liver to relieve pain. It is a common “medicine pair” for dispersing cold and relieving pain, and is used clinically to treat tumor-induced pain in the limbs and internal organs caused by liver stagnation and cold condensation. 6.Aconite + whole scorpion The combination of the two has a strong effect of warming the meridians and dispersing cold, dispelling wind and dampness, and relieving pain, which is quite suitable for cancer pain. These two drugs are toxic, and the tolerance of each person varies, so strict attention should be paid to the dose in clinical treatment, and it is safer to start with a small dose. (7) Conclusion: In-depth research on the experience of drug pairing in the treatment of tumors can improve the efficacy, expand the scope of drug application and reduce the toxic side effects of drugs. At the same time, it is also very important to carry out the research of Chinese medicine compounding, analyze the main structure of Chinese medicine prescriptions, and master the law of drug formulation.