After the diagnosis of severe acute pancreatitis is clear, the corresponding treatment mainly includes the following aspects: 1. fasting, after the clinical judgment, some patients need gastrointestinal decompression, in addition to fasting and gastrointestinal decompression, but also the monitoring of vital signs to determine the changes in the clinical occurrence and development of pancreatitis; 2. medication, now the larger part of patients with pancreatitis are controlled by drugs, mainly control the secretion of the pancreas. There are many drugs used now, including the most clinically used octreotide and growth inhibitors, which are used to control the occurrence and development of pancreatitis by reducing the secretion of the pancreas, and drugs that inhibit the activation of pancreatic enzymes, such as ustekin or gabapentin, which can reduce the activation of pancreatic enzymes and control the occurrence of pancreatitis; 3. The most important is the supportive treatment of other organs, which is very important for severe pancreatitis. Organ support therapy, including airway management, ventilator assisted breathing, and maintenance of liver function and kidney function, plays a very important role. Currently, the most used treatment is blood purification, which is widely used in the treatment of severe pancreatitis. For some hyperlipidemia, especially severe pancreatitis, blood purification can play a very important role.