Swelling with soreness between the ear root and mandible may be related to temporomandibular joint disorder, mumps, odontogenic infection, etc. Different treatments need to be taken according to the specific cause of the disease, such as the use of aminoglucose sulfate capsule, injectable penicillin sodium, clarithromycin capsule and other medications, which are recommended to be used under the guidance of a doctor. 1. Temporomandibular joint disorder: it is one of the more common diseases in stomatology, often with pain in the joint area, jaw movement disorders, joint popping during movement, temporal pain and so on as the main symptom. The swelling and soreness between the ear root and the jawbone may be TMJ disorder, which can be treated with drugs such as glucosamine sulfate capsule and dexamethasone acetate tablets as prescribed by the doctor. 2. Mumps: It is an acute respiratory infectious disease caused by the mumps virus invading the parotid gland, which can manifest as swelling and pain under one or both earlobes. The swelling and soreness between the ear root and the jawbone may be caused by mumps, which can be treated with injectable penicillin sodium, cefuroxime granules and other drugs as prescribed by the doctor. 3. Odontogenic infection: such as plaque caused by periodontal disease, pulpitis, caries and other infections can be through the root tip and periodontal tissues, so that the infection to the jawbone and peri-mandibular cellular tissues diffusion, spreading, which can cause between the ear root and the jawbone enlargement and soreness of the situation. This condition can be treated with anti-infective drugs such as clarithromycin capsules and tinidazole tablets as prescribed by the doctor. The presence of the above factors should be treated under the guidance of a doctor.