At present, intramuscular injection of progesterone is still the most common route of administration for luteal support after in vitro fertilization-embryo transfer (IVF). Because progesterone injection is an oil, it is difficult to inject, and long-term intramuscular injection often causes local sclerosis with redness, swelling, pain, itching and other adverse reactions, which on the one hand causes pain to the patient, and on the other hand affects the absorption of the drug, which in turn may lead to lower pregnancy rate and higher early abortion rate after successful implantation. How to prevent hard knots can be done by gently patting the injection site several times before the injection, using local muscle relaxation while promoting accelerated local blood flow. 2-3 h after the injection (because it takes 2-3 h for the needle eye to close completely after the injection) you can apply hot compresses to the injection site to improve blood circulation, promote the dissipation and absorption of the drug, and prevent the possibility of hard knots. If a hard knot has occurred, it can be treated by the following methods: 1. Hot towel wet compress: This is the most common method we use, and is also the most convenient and effective method. Patients can use a warm towel to apply to the injection site for 30-60 minutes 2-3 times/day, 2-3 hours after the daily intramuscular injection of progesterone. Be sure not to apply hot compresses immediately after the injection, because the eye of the needle needs 2-3h to completely close, immediate hot compresses will cause extravasation of the drug or microbial entry, causing redness, swelling, itching and other inflammatory reactions! 2, potato slices (potato slices) paste: with fresh potatoes washed and cut into 1 ~ 50px after thin slices covered with intramuscular injections, with adhesive tape fixed, external potato slices help to relieve the local hard knots caused by intramuscular injection of progesterone, and has anti-inflammatory, pain relief, blood circulation and swelling function. Be sure to wash clean to prevent infection! 3, the external application of Chinese medicine: because rhubarb has the function of activating blood and dispelling silt, mannitol can be used externally to clear heat and reduce swelling, so for large, hard nodules, Chinese medicine can be used: rhubarb 50g, mannitol 50g, prepare dry research into froth, and then add vinegar to apply externally to the hard nodules. (Please use under the guidance of a doctor) 4.Onion juice plus honey treatment method: first wash the hard nodes with warm water and wipe dry. Use cotton swab to dip onion juice and honey to apply on the hard nodes, the area of application is slightly larger than the area of red and swollen hard nodes, 4 times/day. 5.Eshaacridine lactate is applied topically on the affected area: put gauze into 0.1% Eshaacridine lactate and soak it in wet, the thickness of gauze is 3~4 layers, wring half dry and then put it on the affected area, change once every 10min for 30min, twice a day, 10 days as a course of treatment. (Please use under the guidance of doctor)