Irregularly shaped lymph nodes are most often seen in malignant tumors, but they are not always malignant. Normal lymph node morphology is usually regular, in the shape of a kidney or an oval, etc. Various inflammatory conditions can lead to diffuse hyperplasia of the lymph nodes, but the morphology is usually normal. In contrast, malignant tumors, such as non-Hodgkin’s lymphoma, metastatic carcinoma, etc., often result in the loss of normal morphology of the nodes, which is due to the invasion of tumor cells within the nodes resulting in uneven growth, and its irregular morphology is visible on physical examination or imaging. In addition, the lymph nodes metastasized by malignant tumor cells may also appear to be fused with each other, resulting in irregular shape. However, the regularity of lymph node shape alone cannot determine whether the disease is benign or malignant, and the diagnosis should be confirmed by pathological examination. It is recommended that the patient should consult the doctor in time, and under the doctor’s guidance, take into account the medical history and other auxiliary examinations to clarify the nature of the disease, and if necessary, the feasibility of pathologic examination.