Prednisone acetate tablets and methotrexate are not normally recommended to be taken together, but if the condition is serious and there are no obvious contraindications, they can be taken under the guidance of a doctor at the appropriate dose for a short period of time. Prednisone acetate tablets belong to the glucocorticoid drugs, with anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressive effects. This drug is commonly used in allergic diseases, autoimmune inflammatory diseases. Large doses of this product can cause Cushing-like syndrome symptoms, diabetes, peptic ulcers, concurrent infections and other adverse reactions. It needs to be contraindicated in people who are allergic to this product, thrombosis, and peptic ulcers. Methotrexate belongs to immunosuppressant, with immunosuppressive effect, can be used for all types of acute leukemia, lung cancer, psoriasis, ovarian cancer, testicular cancer, malignant staphylococcus, choriocarcinoma and so on. This drug can cause stomatitis, pharyngitis, nausea, vomiting, diarrhea, liver function impairment, bone marrow suppression, and risk of concurrent infections. It is contraindicated in people who are highly allergic to this product. Prednisone acetate tablets, when combined with immunosuppressive agents (e.g. methotrexate, etc.), can increase the risk of severe infections, and can also induce lymphoma, or other lymphoproliferative disorders. Therefore it is usually not recommended to take them together. However, if the condition is serious and there are no obvious contraindications, it can be taken under the guidance of a doctor at the appropriate dose for a short period of time, and can be used to fight infections if necessary. Precautions: after long-term administration of prednisone acetate tablets, the dosage should be gradually reduced when the drug is discontinued. Methotrexate has the potential risk of causing secondary tumors after long-term administration. It is recommended that the medication be used reasonably under the guidance of a doctor, do not self-medicate.