Overview: Malignant tumors originating in the laryngopharynx are rare. The incidence rate of laryngopharyngeal cancer in foreign countries is 0.8/100,000; the data in China show that the incidence rate is 0.15/100,000 for men and 0.02/100,000 for women. Laryngopharyngeal malignant tumor accounts for 1.4% of head and neck malignant tumors and 0.2% of systemic malignant tumors. The most common age is 50~70 years old. Causes: Excessive smoking and alcohol: benzopyrene in tobacco tar has carcinogenic effect; alcohol can not only stimulate mucous membrane to induce mucosal epithelial dystrophy, but also promote the carcinogenic effect of smoke. 2. Malnutrition: ischemic anemia can lead to thinning of mucous membrane of laryngopharynx, reduction or lack of intracellular glycogen, extensive atrophy of pharyngeal and esophageal mucous membrane, which is easy to occur laryngopharyngeal and cervical esophageal cancer. 3. Viral infection: under certain conditions, EB virus and human papilloma virus may cause cancer. 4. Gastroesophageal reflux, esophageal cancer causes: 1. Nitrosamines carcinogenic 2. Moldy food carcinogenic 3. Lack of trace elements (molybdenum, copper, zinc, etc.) 4. Genetic susceptibility 5. Chronic inflammation of esophagus Clinical manifestations: 1. Pharyngeal foreign body sensation: a sense of food residue after eating 2. Swallowing pain: more and more severe and severe and can be radiating to the ear of the one side 3. Hoarseness: 5, cough or choking 6, neck mass (upper or middle neck): about 1/3 of patients, the pharynx can be asymptomatic, and cervical lymph node enlargement as the first symptom. Examination: 1, indirect laryngoscopy: simple method, but some patients can not tolerate or poor exposure 2, fiber laryngoscope or electronic laryngoscopy: can be intuitive, clear observation of the laryngopharyngeal cavity 3, neck examination: first check the outside of the larynx, observation of the thyroid cartilage shape whether the widening of the laryngeal friction sound disappears; initial diagnosis of the presence or absence of enlarged lymph nodes. 4, Neck imaging: it can initially determine the location of the tumor, and the infiltration range of the tumor or its relationship with adjacent organs (larynx, trachea, cervical vessels and nerves). 5.Esophageal imaging: it can see the mucosal abnormality, filling defect, and observe the scope of tumor. 6.Pathological examination: it is very important for clear diagnosis. Treatment: Early laryngopharyngeal cancer and cervical esophageal cancer are treated with radiation or surgery alone, and their curative effects are similar. Patients with advanced stage should adopt comprehensive treatment of both. I. Radiotherapy: Early stage patients should be treated with simple radiotherapy (radical radiotherapy): the total amount is 60-70Gy, which should be completed in 6-7 weeks. Radiosurgery comprehensive treatment, preoperative amount in 40 ~ 50Gy, completed in 4 ~ 5 weeks, radiotherapy after resting 2 ~ 4 weeks surgery. Postoperative radiotherapy should be started within 6 weeks, and the amount of radiotherapy should be 50-60Gy. Surgery: Early stage can be simple surgical resection of primary cancer foci, and selective or radical cervical lymph node dissection can be performed at the same time. Surgical methods are selected according to different clinical stages. In the middle and late stages, the resection range is larger and trauma is also larger, which often needs to be repaired or restored. III. Comprehensive treatment It is generally believed that for middle and late stage cancer, the planned simultaneous or before and after application of various existing treatments (preoperative radiotherapy, postoperative radiotherapy, induction chemotherapy plus radiotherapy or chemotherapy) has been proved to have the effect of improving the local control rate and survival rate. Prognosis: Among head and neck tumors both are among the more difficult to treat and less effective. In general, the 5-year survival rate after radiotherapy is about 10-20%. The 5-year survival rate of surgical treatment is about 30～40%. In some studies, once the lymph node metastasis, the chance of radical treatment will be reduced by 30-50%. Therefore, early diagnosis and early treatment are very important to improve the survival rate.