Some of the more common causes of overflow proteinuria are multiple myeloma, hemolysis, rhabdomyolysis, and so on. Overflow proteinuria is a condition in which the body produces more protein than the tubules of the kidneys can reabsorb, and this is called overflow proteinuria when protein is detected in the urine. The most common form is multiple myeloma, which produces very high levels of immunoglobulins and their components. Urinary protein can be detected in the urine routine, and urine periplasmic protein, which is a component of immunoglobulins, is also positive. After hemolysis occurs, hemoglobin is released from the red blood cells and is also filtered through the kidneys, resulting in positive urine protein. Rhabdomyolysis is caused by muscle damage, resulting in the discharge of large amounts of myoglobin, which exceeds the tubular reabsorption capacity as it passes through the kidneys, and can be detected in the urine routine. As can be seen here, the diseases included in overflow proteinuria are very numerous and need to be identified and then managed.